pentosan injection

pentosan injection actively reverses the effects of osteoarthritis in the joints via a series of actions, including: Stimulating Chondrocyte Metabolism -resulting in increased production of proteoglycans and healthy cartilage matrix. PPS stimulates synovial fibroblasts to produce increased amounts of high molecular weight hyaluronic acid which results in an increased production of normally viscous joint fluid. Improving the fluid volume and consistency results in more effective joint lubrication and stabilisation, which limits further cartilage damage. pentosan injection

Anti-inflammatory Activity -PPS has an inhibitory action on all mediators of the 6 mL sterile Injection arachidonic acid cascade. PPS also inhibits the lysosomal catabolic enzymes hyaluronidase, histamine, cathepsin B, and polymorphonuclear elastase.

PPS exerts a specific inhibitory effect on mediators implicated in the degradation of cartilage matrix components, preserving the cartilage and preventing the release of the highly inflammatory mediators, thus relieving pain and inflammation. Fibrinolysis and Lipolysis – PPS is strongly fibrinolytic, stimulating the release of plasminogen activator, and promoting the dissolution of thrombi and fibrin deposits in synovial tissues and subchondral blood vessels PPS also mobilises lipids and cholesterol in synovial and subchondral blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals

These effects combine to increase the prefusion to the joint, which stimulates cartilage healing and repair.

pentosan injection  is a sophisticated approach to the long term management of osteoarthritis in horses.